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[暴露于胃癌致癌物N-乙基-N1-硝基-N-亚硝基胍的猴子胃中DNA修复酶O(6)-烷基鸟嘌呤-DNA烷基转移酶活性的个体特征]

[The individual characteristics of the activity of the DNA-repair enzyme O(6)-alkylguanine-DNA alkyltransferase in the stomach of monkeys exposed to the gastric carcinogen N-ethyl-N1-nitro-N-nitrosoguanidine].

作者信息

Loktionova N A, Beniashvili D Sh, Zabezhinskiĭ M A, Kazanova O I, Petrov A S, Likhachev A Ia

出版信息

Vopr Onkol. 1992;38(8):961-8.

PMID:1300807
Abstract

Variations in the activity of a DNA repair enzyme 0(6)-alkylgianine-DNA alkyltransferase (AGT) were studied in gastric mucosa samples obtained from 15 M. fascicularis monkeys chronically exposed to a gastrocarcinogen N-ethyl-N'-nitro-N-nitrosoguanidine. Marked interindividual difference in the enzyme activity before and in the course of the exposure was observed. The value of AGT activity assay to predict individual susceptibility to alkylating carcinogens is discussed.

摘要

在从15只长期暴露于胃致癌物N-乙基-N'-硝基-N-亚硝基胍的食蟹猴获取的胃黏膜样本中，研究了DNA修复酶O(6)-烷基鸟嘌呤-DNA烷基转移酶（AGT）活性的变化。观察到暴露前及暴露过程中酶活性存在明显的个体差异。讨论了AGT活性测定在预测个体对烷基化致癌物易感性方面的价值。

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