Perego M A, Danese C, Volpe M S, Zavattaro E, Calisi L
Medical Unit 2, Policlinico Umberto 1, Roma, Italia.
Ann Cardiol Angeiol (Paris). 1992 Dec;41(10):A75-80.
Eleven healthy volunteers were examined, as well a thirty-five diabetic subjects divided into three groups according to the presence or absence of macro-microvascular complications and according to whether or not these complications were chronic. The results of our study show a marked unfavorable in cell rheology in the diabetic subjects, as studied using the St. George filtrometer. In particular, polymorphonuclear (PMN) cells, in the diabetic subject showed a substantial decreases in viscosity and elasticity, reflected by decreased IrFr and increased CR values. These changes were most marked in the group of diabetics with acute vascular events, i.e., AMI and stroke. Rheological indexes studied appeared to be independent from the simultaneous blood glucose level.
我们检查了11名健康志愿者，以及35名糖尿病患者，这些糖尿病患者根据是否存在大微血管并发症以及这些并发症是否为慢性被分为三组。我们的研究结果表明，使用圣乔治滤过仪研究发现，糖尿病患者的细胞流变学存在明显的不利情况。特别是，糖尿病患者的多形核（PMN）细胞显示出粘度和弹性大幅下降，这通过IrFr降低和CR值升高得以体现。这些变化在患有急性血管事件（即急性心肌梗死和中风）的糖尿病患者组中最为明显。所研究的流变学指标似乎与同时期的血糖水平无关。
