Cella A, Bianchi E, Reali G L, Piana A, Armani U
Istituto Scientifico di Medicina Interna, Università degli Studi di Genova.
Boll Soc Ital Biol Sper. 1990 Apr;66(4):335-42.
It has been speculated that changes in intrinsic blood flow properties may contribute to the evolution of vascular complications in diabetes mellitus. To verify this hypothesis we measured hematocrit, fibrinogen, plasma and blood viscosity in 30 diabetic patients and in 25 healthy volunteers. Diabetics showed blood and plasma viscosity and fibrinogenemia higher than healthy subjects, although only plasma viscosity and fibrinogenemia were statistically significant (p less than 0.001). Moreover the diabetic patients with the highest HbAlc values had a significant increase in plasma viscosity compared with the patients with lower HbAlc values (p less than 0.001), despite a similar fibrinogenemia. This study confirms the presence of hemorheological changes in diabetes mellitus and shows a correlation between plasma viscosity and metabolic control.
据推测，内在血流特性的改变可能有助于糖尿病血管并发症的发展。为了验证这一假设，我们测量了30名糖尿病患者和25名健康志愿者的血细胞比容、纤维蛋白原、血浆和血液粘度。糖尿病患者的血液和血浆粘度以及纤维蛋白原血症高于健康受试者，尽管只有血浆粘度和纤维蛋白原血症具有统计学意义（p<0.001）。此外，糖化血红蛋白（HbAlc）值最高的糖尿病患者与HbAlc值较低的患者相比，血浆粘度显著增加（p<0.001），尽管纤维蛋白原血症相似。这项研究证实了糖尿病患者存在血液流变学变化，并表明血浆粘度与代谢控制之间存在相关性。
