[头孢噻肟在实验性鼠疫感染中的有效性]
[Effectiveness of cefotaxime in experimental plague infection].
作者信息
Makarovskaia L N, Shcherbaniuk A I, Kasatkina I V, Zurabian V A
出版信息
Antibiot Khimioter. 1992 Nov;37(11):24-6.
PMID:1300929
Abstract
Cefotaxime was shown highly efficient in prophylaxis and treatment of experimental plague infection in albino mice. The in vitro activity of cefotaxime against natural strains of the plague microbe was 32 to 64 times higher than that of cefazolin, cephalothin and cefmetazole. The combined use of cefotaxime with amikacin significantly increased the percentage of the survived albino mice with plague infection as compared to the use of the antibiotics alone.
摘要
头孢噻肟在预防和治疗白化小鼠实验性鼠疫感染方面显示出高效性。头孢噻肟对鼠疫杆菌天然菌株的体外活性比头孢唑林、头孢噻吩和头孢美唑高32至64倍。与单独使用抗生素相比，头孢噻肟与阿米卡星联合使用显著提高了鼠疫感染白化小鼠的存活百分比。
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