Ivanova I V, Khristova K G, Tishkov S Kh, Moncheva P A
Antibiot Khimioter. 1992 Nov;37(11):3-5.
The influence of protoplasting and protoplast regeneration in the presence of polyethylene glycol on antibiotic activity, components of antibiotic complexes and antibiotic resistance in Streptomyces hygroscopicus 155 was studied. It was shown that the protoplasting and protoplast regeneration influenced the antibiotic activity. The protoplast fusion resulted in increased isolation of variants with higher antibiotic activity. The processes also affected the components of the antibiotic complexes but had no effect on the strain resistance to some antibiotics.
研究了在聚乙二醇存在下原生质体形成和原生质体再生对吸水链霉菌155抗生素活性、抗生素复合物成分及抗生素抗性的影响。结果表明，原生质体形成和原生质体再生影响抗生素活性。原生质体融合导致分离出抗生素活性更高的变体。这些过程也影响抗生素复合物的成分，但对该菌株对某些抗生素的抗性没有影响。
