子宫切除术后的雌激素替代疗法。
Oestrogen replacement therapy after hysterectomy.
作者信息
Seeley T
出版信息
BMJ. 1992 Oct 3;305(6857):811-2. doi: 10.1136/bmj.305.6857.811.
OBJECTIVE
To identify those women who might benefit from oestrogen replacement after hysterectomy.
DESIGN
Targeted health screening.
SETTING
Large group practice.
SUBJECTS
All women aged under 50 who had had a hysterectomy.
MAIN OUTCOME MEASURES
Concentration of follicle stimulating hormone, symptom profile, uptake of oestrogen replacement therapy.
RESULTS
145 of 1953 women aged 32-49 had had a hysterectomy. 35 of the 41 with bilateral oophorectomy and 27 of 104 with one or more ovaries conserved were taking oestrogen replacement. 62 of the 68 who had ovaries conserved and were not taking oestrogen replacement attended for review, of whom 14 had a follicle stimulating hormone concentration > or = 20 IU/l. 16 of the 19 women identified as potentially able to benefit from oestrogen replacement started treatment and were still on treatment at six months of follow up.
CONCLUSION
Systematic review of women who had had a hysterectomy identified an important group who would potentially benefit from oestrogen replacement therapy.
目的
确定那些子宫切除术后可能从雌激素替代治疗中获益的女性。
设计
针对性健康筛查。
地点
大型团体诊所。
研究对象
所有年龄在50岁以下且已接受子宫切除术的女性。
主要观察指标
促卵泡激素浓度、症状表现、雌激素替代疗法的接受情况。
结果
1953名年龄在32 - 49岁的女性中，有145人接受了子宫切除术。41例行双侧卵巢切除术的女性中有35人、104例保留一个或多个卵巢的女性中有27人正在接受雌激素替代治疗。68例保留卵巢且未接受雌激素替代治疗的女性中有62人前来复诊，其中14人促卵泡激素浓度≥20 IU/l。确定的19名可能从雌激素替代治疗中获益的女性中有16人开始治疗，在随访6个月时仍在接受治疗。
结论
对子宫切除术后女性进行系统评估，确定了一个可能从雌激素替代治疗中获益的重要群体。
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