Gelfand M C, Schur P H, Asofsky R, Steinberg A D
Arthritis Rheum. 1976 Jan-Feb;19(1):43-8. doi: 10.1002/art.1780190107.
Azathioprine, cyclophosphamide, and methylprednisolone given individually to NZB/NZW mice retard the development of autoimmune nephritis and prolong survival in these mice. Administration of the combination of all three drugs is superior to one or two drug regimens. In the present study the kidneys of mice treated with all single, double, and triple drug regimens were compared for the degree of deposition of immunoglobulin and complement. The triple drug regimen significantly reduced overall deposition of immunoglobulin and complement compared with any other regimen. Complement and gamma2 were significantly reduced by triple drug therapy compared with any other regimen. The triple drug regimen reduced gamma1 compared with untreated and double drug treated mice. The single, double, and triple drug regimens significantly reduced gammaM deposition to about the same degree. Deposition of gammaA was not significantly reduced by any regimen. Circulating levels of these immunoglobulin classes were not reduced, a fact suggesting that the reduction in autoimmune nephritis resulting from triple drug therapy is associated with superior reduction in immune complex deposition rather than with generalized, non-specific immunodepression.
单独给予NZB/NZW小鼠硫唑嘌呤、环磷酰胺和甲基强的松龙可延缓自身免疫性肾炎的发展并延长这些小鼠的生存期。三种药物联合使用优于单一或两种药物治疗方案。在本研究中，对接受所有单一、双重和三重药物治疗方案的小鼠肾脏进行了免疫球蛋白和补体沉积程度的比较。与任何其他治疗方案相比，三重药物治疗方案显著降低了免疫球蛋白和补体的总体沉积。与任何其他治疗方案相比，三重药物治疗显著降低了补体和γ2。与未治疗和接受双重药物治疗的小鼠相比，三重药物治疗方案降低了γ1。单一、双重和三重药物治疗方案将γM沉积显著降低到大致相同的程度。任何治疗方案均未显著降低γA的沉积。这些免疫球蛋白类别的循环水平未降低，这一事实表明，三重药物治疗导致的自身免疫性肾炎的减轻与免疫复合物沉积的显著减少有关，而不是与全身性、非特异性免疫抑制有关。
