用环孢素和（Nva2）-环孢素成功治疗（NZB×NZW）F1小鼠自身免疫：II. 肾小球肾炎的减轻
Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.
作者信息
Gunn H C, Ryffel B
出版信息
Clin Exp Immunol. 1986 May;64(2):234-42.
Abstract
Autoimmune (NZB X NZW)F1 mice were treated with the immunosuppressive agent, cyclosporin, and its new derivative (Nva2)-cyclosporin. Both compounds prevented the deposition of immunocomplexes in the kidneys, and the subsequent development of glomerulonephritis and proteinuria in young mice. They also reduced established proteinuria in old mice. Therefore, we feel that both cyclosporin and (Nva2)-cyclosporin may be useful in the treatment of human glomerulonephritis where there is an autoimmune component.
摘要
用免疫抑制剂环孢素及其新衍生物（Nva2）-环孢素处理自身免疫性（NZB×NZW）F1小鼠。两种化合物均可防止免疫复合物在肾脏中沉积，以及预防幼鼠随后发生的肾小球肾炎和蛋白尿。它们还能减轻老龄小鼠已有的蛋白尿。因此，我们认为环孢素和（Nva2）-环孢素在治疗存在自身免疫成分的人类肾小球肾炎中可能有用。
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