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环磷酰胺对NZB/NZW疾病的保护作用。作用机制与治疗方案。

Cyclophosphamide protection in NZB/NZW disease. Mechanisms and therapeutic regimens.

作者信息

Morris A D, Esterly J, Chase G, Sharp G C

出版信息

Arthritis Rheum. 1976 Jan-Feb;19(1):49-55. doi: 10.1002/art.1780190108.

DOI:10.1002/art.1780190108
PMID:130137
Abstract

Regular administration of cyclophosphamide to NZB/NZW female mice effectively protects against the nephritis that is thought to be a model for human SLE nephritis. Reductions in serologic, histologic, and immunogluorescent parameters of the disease are correlated. Intermittent as well as continuous administration of the drug is effective without the development of leukopenia. Possible mechanisms of drug action and a modified approach to therapy of immune complex disease are discussed.

摘要

对NZB/NZW雌性小鼠定期给予环磷酰胺可有效预防被认为是人类系统性红斑狼疮肾炎模型的肾炎。该疾病的血清学、组织学和免疫荧光参数的降低是相关的。间歇性和持续性给药均有效，且不会出现白细胞减少症。文中讨论了药物作用的可能机制以及免疫复合物疾病治疗的改良方法。

相似文献

1
Cyclophosphamide protection in NZB/NZW disease. Mechanisms and therapeutic regimens.环磷酰胺对NZB/NZW疾病的保护作用。作用机制与治疗方案。
Arthritis Rheum. 1976 Jan-Feb;19(1):49-55. doi: 10.1002/art.1780190108.
2
Therapeutic studies in NZB/W mice. IV. Effect of combination drug therapy on immune complex deposition.新西兰黑/白小鼠的治疗研究。IV. 联合药物治疗对免疫复合物沉积的影响。
Arthritis Rheum. 1976 Jan-Feb;19(1):43-8. doi: 10.1002/art.1780190107.
3
Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease.新西兰小鼠自身免疫的遗传学研究。IV. NZB和NZW基因对（NZB×NZW）F1杂种中逆转录病毒gp70免疫复合物自发出现的贡献及其与肾脏疾病的相关性。
J Immunol. 1983 Feb;130(2):740-6.
4
The mechanism of action of cyclophosphamide on the nephritis of (NZB x NZW)F1 hybrid mice.环磷酰胺对（新西兰黑鼠×新西兰白鼠）F1杂交小鼠肾炎的作用机制。
Clin Exp Immunol. 1977 Jul;29(1):132-9.
5
Influence of cyclophosphamide and other immunosuppressive drugs on immune disorders and neoplasia in NZB/NZW mice.环磷酰胺及其他免疫抑制药物对NZB/NZW小鼠免疫紊乱和肿瘤形成的影响。
Arthritis Rheum. 1975 Mar-Apr;18(2):145-52. doi: 10.1002/art.1780180212.
6
High incidence of neoplasms in female NZB/NZW mice treated with pulse doses of cyclophosphamide.用脉冲剂量环磷酰胺处理的雌性新西兰黑/新西兰白小鼠肿瘤发生率高。
Vet Immunol Immunopathol. 1983 Nov;5(1):97-104. doi: 10.1016/0165-2427(83)90035-1.
7
Prostaglandin E1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis.前列腺素E1对NZB/NZW F1杂交小鼠的治疗。II. 肾小球肾炎的预防
Arthritis Rheum. 1977 Nov-Dec;20(8):1449-56. doi: 10.1002/art.1780200802.
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Acceleration of glomerulonephritis in NZB x NZW mice by early immunization with DNA and injection of bacterial lipopolysaccharide. Experimental approach to the treatment of lupus nephritis by use of the accelerated model of NZB x NZW mouse disease.通过早期DNA免疫和注射细菌脂多糖加速NZB×NZW小鼠的肾小球肾炎。利用NZB×NZW小鼠疾病的加速模型治疗狼疮性肾炎的实验方法。
J Clin Lab Immunol. 1980 Sep;4(2):103-6.
9
Alteration of lymphocyte function in NZB/NZW mice. IV. Response to levamisole.NZB/NZW小鼠淋巴细胞功能的改变。IV. 对左旋咪唑的反应。
Arthritis Rheum. 1979 Mar;22(3):236-42. doi: 10.1002/art.1780220305.
10
An Ig mu-heavy chain transgene inhibits systemic lupus erythematosus immunopathology in autoimmune (NZB x NZW)F1 mice.一种免疫球蛋白μ重链转基因可抑制自身免疫性（NZB×NZW）F1小鼠的系统性红斑狼疮免疫病理学。
Int Immunol. 2001 Dec;13(12):1461-9. doi: 10.1093/intimm/13.12.1461.

引用本文的文献

1
Placebo and the new physiology of the doctor-patient relationship.安慰剂与医患关系的新生理学。
Physiol Rev. 2013 Jul;93(3):1207-46. doi: 10.1152/physrev.00043.2012.
2
Long term administration of cyclophosphamide in MRL/1 mice. I. The effects on the development of immunological abnormalities and lupus nephritis.环磷酰胺对MRL/1小鼠的长期给药。I. 对免疫异常和狼疮性肾炎发展的影响。
Clin Exp Immunol. 1984 Feb;55(2):333-9.
3
Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.小鼠狼疮性肾炎：环磷酰胺对循环及组织结合免疫反应物的影响
Clin Exp Immunol. 1984 Jan;55(1):67-73.
4
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.用抗I-A单克隆抗体治疗（新西兰黑鼠×新西兰白鼠）F1代疾病。
J Exp Med. 1983 Oct 1;158(4):1350-5. doi: 10.1084/jem.158.4.1350.
5
Effects of pulse cyclophosphamide on NZB/W disease.脉冲环磷酰胺对NZB/W疾病的影响。
Immunology. 1981 May;43(1):57-65.
6
Effect of cyclophosphamide on glomerular permeability and localization of immunoreactants in NZB/NZW mice.环磷酰胺对NZB/NZW小鼠肾小球通透性及免疫反应物定位的影响。
Clin Exp Immunol. 1982 Apr;48(1):79-84.
7
Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.用环孢素和（Nva2）-环孢素成功治疗（NZB×NZW）F1小鼠自身免疫：II. 肾小球肾炎的减轻
Clin Exp Immunol. 1986 May;64(2):234-42.
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Effects of dazmegrel, piroxicam and cyclophosphamide on the NZB/W model of SLE.达美格雷、吡罗昔康和环磷酰胺对NZB/W狼疮模型的影响。
Agents Actions. 1989 Jun;27(3-4):369-74. doi: 10.1007/BF01972825.
9
Murine mercury-induced immune-complex disease: effect of cyclophosphamide treatment and importance of T-cells.小鼠汞诱导的免疫复合物疾病：环磷酰胺治疗的效果及T细胞的重要性
Br J Exp Pathol. 1989 Jun;70(3):227-36.
10
Effect of pulse dose cyclophosphamide on the anamnestic immune response in NZB/W mice.脉冲剂量环磷酰胺对NZB/W小鼠回忆性免疫反应的影响。
Agents Actions. 1978 Dec;8(6):644-51. doi: 10.1007/BF01998895.