Levy L, Chia D, Barnett E V
Agents Actions. 1978 Dec;8(6):644-51. doi: 10.1007/BF01998895.
Mice exhibiting a spontaneous SLE-like lethal autoimmunity (female NZB/W hybrids) were given monthly doses of cyclophosphamide (CPA) 240 mg/kg p.o. starting at four months of age. Antibodies to DNA and sheep red blood cells (SRBC) were measured as well as general well being of the mice. The CPA-treated group demonstrated a marked increased in survival compared to the untreated controls with reduction of anti-DNA antibody levels but only a slight inhibition of the anamnestic response to SRBC immunization.
对表现出自发性狼疮样致死性自身免疫的小鼠（雌性新西兰黑/白杂交小鼠），从4月龄开始每月口服给予240mg/kg环磷酰胺（CPA）。检测了小鼠的抗DNA抗体、抗绵羊红细胞（SRBC）抗体以及整体健康状况。与未治疗的对照组相比，CPA治疗组小鼠的存活率显著提高，抗DNA抗体水平降低，但对SRBC免疫的回忆反应仅有轻微抑制。
