Pacifici L, Bellucci A, Piovesan P, Maccari F, Gorio A, Ramacci M T
Institute for Research on Senescence, Sigma-Tau, Pomezia, Rome, Italy.
Int J Clin Pharmacol Res. 1992;12(5-6):231-6.
The effect of levocarnitine acetyl on diabetic peripheral neuropathy induced by a single injection of streptozotocin or alloxan was studied. Levocarnitine acetyl was administered intraperitoneally one week after induction of diabetes at the dose of 50 mg/kg/day for five and ten weeks. At the end of treatment, neuromuscular conduction velocity (m/sec) was evaluated by stimulating the sciatic nerve and recording the soleus muscle potentials evoked, and the muscle contraction force (mm) by measuring the isometric muscular tension. Motor coordination was evaluated on the Rota-rod apparatus. Treatment with levocarnitine acetyl fully prevented the reduction (20%) in the neuromuscular conduction velocity observed in both experimental models of diabetes. The decrease (30-33%) in muscle contraction force was prevented partially in streptozotocin-induced diabetes and fully in alloxan-induced diabetes. Levocarnitine acetyl also improved the concomitantly reduced motor performance. The results of the present study suggest a beneficial effect of levocarnitine acetyl on peripheral neuropathy and muscle performance.
研究了左旋肉碱乙酰酯对单次注射链脲佐菌素或四氧嘧啶诱导的糖尿病性周围神经病变的影响。在糖尿病诱导一周后，以50毫克/千克/天的剂量腹腔注射左旋肉碱乙酰酯，持续5周和10周。治疗结束时，通过刺激坐骨神经并记录诱发的比目鱼肌电位来评估神经肌肉传导速度（米/秒），并通过测量等长肌肉张力来评估肌肉收缩力（毫米）。在旋转杆装置上评估运动协调性。左旋肉碱乙酰酯治疗完全预防了在两种糖尿病实验模型中观察到的神经肌肉传导速度降低（20%）。在链脲佐菌素诱导的糖尿病中，肌肉收缩力的降低（30 - 33%）得到部分预防，而在四氧嘧啶诱导的糖尿病中则得到完全预防。左旋肉碱乙酰酯还改善了同时降低的运动表现。本研究结果表明左旋肉碱乙酰酯对周围神经病变和肌肉表现具有有益作用。
