Di Giulio A M, Gorio A, Bertelli A, Mantegazza P, Ferraris L, Ramacci M T
Department of Medical Pharmacology, University of Milan, Italy.
Int J Clin Pharmacol Res. 1992;12(5-6):243-6.
Diabetic neuropathy is a disease of peripheral nerves, characterized by axonal atrophy and degeneration that might be preceded by a marked impairment of axonal transport and by a reduced conduction velocity. Sensory nerves are particularly susceptible to diabetes. In the present report it is shown that experimental diabetes in rats causes a significant reduction of the content of the pain-related neuropeptide substance P in sciatic nerve and lumbar spinal cord. Such a loss of substance P is fully prevented by acetyl-L-carnitine treatment. The neuroprotective pharmacological effect is selective and takes place without significant changes of hyperglycaemia and without modifications of the reduced rate of body growth typical of diabetic animals.
糖尿病性神经病变是一种周围神经疾病，其特征为轴突萎缩和变性，在此之前可能会出现轴突运输的显著受损以及传导速度降低。感觉神经对糖尿病尤为敏感。本报告显示，大鼠实验性糖尿病会导致坐骨神经和腰脊髓中与疼痛相关的神经肽P物质含量显著降低。乙酰-L-肉碱治疗可完全防止P物质的这种损失。这种神经保护药理作用具有选择性，在血糖没有显著变化以及糖尿病动物典型的身体生长速率降低没有改变的情况下发生。
