Scarfò C, Falcinelli M, Pacifici L, Bellucci A, Reda E, De Angelis C, Ramacci M T, Angelucci L
Institute for Research on Senescence, Sigma Tau S.p.A. Pomezia, Rome, Italy.
Int J Clin Pharmacol Res. 1992;12(5-6):253-62.
The effects of levocarnitine acetyl on structure and function of the sciatic nerve and neuromuscular junctions of the soleus and extensor digitorum longus muscles were studied in the aged rat. To that end, neuromuscular conduction velocity (NMCV) was measured in vivo and morphological and morphometric evaluations were performed. Treatment with levocarnitine acetyl, 150 mg/kg day for six months, restored NMCV values to the levels measured in the young rat; significantly reduced the number of degenerating elements; and increased the number of myelinated fibres having normal structural features. In the soleus and extensor digitorum longus muscles, levocarnitine acetyl increased the complexity of neuromuscular junctions. These experimental findings suggest a neurotrophic action of levocarnitine acetyl on the peripheral nervous system that might have therapeutical applications in age-related peripheral nerve changes.
在老年大鼠中研究了左旋肉碱乙酰酯对坐骨神经以及比目鱼肌和趾长伸肌神经肌肉接头的结构和功能的影响。为此，在体内测量了神经肌肉传导速度（NMCV），并进行了形态学和形态计量学评估。以150mg/kg/天的剂量给予左旋肉碱乙酰酯治疗六个月，可使NMCV值恢复到幼鼠测量的水平；显著减少退变元件的数量；并增加具有正常结构特征的有髓纤维的数量。在比目鱼肌和趾长伸肌中，左旋肉碱乙酰酯增加了神经肌肉接头的复杂性。这些实验结果表明左旋肉碱乙酰酯对周围神经系统具有神经营养作用，这可能在与年龄相关的周围神经变化中具有治疗应用价值。
