Pilch J, Laskawiec J, Lisiewicz J, Gierek T
I Katedry i Kliniki Laryngologii Slaskiej Akademii Medycznej, Katowicach.
Otolaryngol Pol. 1992;46(6):543-52.
The authors presented the results of chemical compounds in the laryngeal cancer tissue in 20 patients with clinically and histologically confirmed plano-epithelial carcinoma using own modification of x-ray microanalysis method. Comparison between the healthy and neoplasmatic tissue showed as follows: 1) both healthy and neoplasmatic tissue showed the presence of Cd, Zn, Fe, Mn, Mg and Si, P, S, Cl, K, Ca, Ti; 2) the neoplasmatic tissue showed the presence of Pb whereas it was not observed in the healthy tissue; 3) both Pb and Cl were irregularly concentrated in the neoplasmatic tissue while in the healthy tissue showed regular concentration. The authors discuss some methodological aspects and try to interpret the obtained data in the view of toxic, mutagenous and carcinogenous role of the Pb.
作者采用自行改进的X射线微分析法，展示了20例临床和组织学确诊为扁平上皮癌的喉癌患者癌组织中的化合物结果。健康组织与肿瘤组织的对比结果如下：1）健康组织和肿瘤组织中均存在镉（Cd）、锌（Zn）、铁（Fe）、锰（Mn）、镁（Mg）、硅（Si）、磷（P）、硫（S）、氯（Cl）、钾（K）、钙（Ca）、钛（Ti）；2）肿瘤组织中存在铅（Pb），而健康组织中未观察到；3）铅和氯在肿瘤组织中呈不规则聚集，而在健康组织中呈规则聚集。作者讨论了一些方法学方面的问题，并试图从铅的毒性、致突变性和致癌性角度解释所获数据。
