Cortesina G, Sacchi M, Bussi M, Panizzut B, Ferro S, Carlevato M T, Marchisio P C
II ENT Department, University of Torino, Italy.
Acta Otolaryngol. 1995 Mar;115(2):328-30. doi: 10.3109/00016489509139322.
Neoplastic transformation results in rearrangement of the cell membrane with a breakdown of the regular expression of adhesion molecules such as integrins. A relationship may exist between the intensity of this alteration, and the form it takes, and a tumour's ability to metastatise. We studied this possibility by investigating the epithelial integrin expression of 35 head and neck squamous cell carcinomas. Two types of positivity were observed: one associated with tumours with a better prognostic index, the other with those characterized by greater malignancy.
肿瘤转化导致细胞膜重排，破坏诸如整合素等黏附分子的正常表达。这种改变的强度、形式与肿瘤的转移能力之间可能存在关联。我们通过研究35例头颈部鳞状细胞癌的上皮整合素表达来探究这种可能性。观察到两种阳性类型：一种与预后指数较好的肿瘤相关，另一种与恶性程度较高的肿瘤相关。
