Bisht R, Goyal A, Singh T, Goyal B K
Department of Ophthalmology and Microbiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh.
Indian J Ophthalmol. 1992 Jul-Sep;40(3):79-82.
Very few immunological studies in vernal catarrh have been conducted in India and abroad, but none in Himachal Pradesh in spite of its high incidence in the State. In the present study 25 patients of vernal catarrh residing at a height ranging between 1000 to 2500 meters above mean sea level have been evaluated. Their immunological status of serum and tears after detailed clinical assessment was studied by single radial immunodiffusion technique of Mancini et al. The values of serum IgA and IgM were significantly higher in patients than in controls. The serum IgE level had no significant difference. The IgG was significantly lower in patients with vernal catarrh. The values of tear IgM, IgE and IgA in these patients were significantly higher than in controls. However, in no case or control group C3C and C4 were detected in tears. The limbal type of vernal catarrh was found to be the most common in this part of the country. No mixed case was seen. Derangement of the immune system in the pathogenesis of vernal catarrh is suggested.
在印度国内外，针对春季卡他性结膜炎开展的免疫学研究极少，尽管喜马偕尔邦该病发病率很高，但该邦却从未开展过此类研究。在本研究中，我们对25名居住在平均海拔1000至2500米之间的春季卡他性结膜炎患者进行了评估。在详细的临床评估之后，采用Mancini等人的单向放射免疫扩散技术对他们血清和泪液的免疫状态进行了研究。患者血清中IgA和IgM的值显著高于对照组。血清IgE水平无显著差异。春季卡他性结膜炎患者的IgG显著较低。这些患者泪液中IgM、IgE和IgA的值显著高于对照组。然而，在任何病例组或对照组的泪液中均未检测到C3C和C4。在该国的这一地区，发现睑裂部型春季卡他性结膜炎最为常见。未见到混合型病例。提示春季卡他性结膜炎发病机制中存在免疫系统紊乱。
