Kisloff B, Moore E W
Gastroenterology. 1977 Mar;72(3):462-8.
The influence of intravenously administered synthetic salmon calcitonin on water, electrolyte and calcium fluxes in in vivo rabbit jejunum and ileum was examined. Rabbits were divided into four groups: those receiving (1) saline intravenously while a glucose-free isotonic saline solution perfused the jejunum and ileum; (2) calcitonin intravenously while the same intestinal perfusate was used as in group 1; (3) intravenous saline while 10 mM glucose-isotonic saline solution perfused jejunum and ileum; and (4) intravenous calcitonin while the intestinal perfusate was of the same composition as in group 3. Calcitonin provoked a significant increase in jejunal and ileal water, sodium, and bicarbonate secretion in both the glucose-free and glucose-containing perfusate groups. No influence on calcium movement was noted. These results, similar to findings of Gray et al. (J Clin Invest 52:3084-3088, 1975) in human jejunum, suggest that calcitonin may play a role in the pathogenesis of the watery diarrhea noted in about one-third of patients with medullary carcinoma of the thyroid. In addition, these studies demonstrate the usefulness of the rabbit as an animal model with which to investigate further the effects of calcitonin upon intestinal fluid and electrolyte transport.
研究了静脉注射合成鲑鱼降钙素对家兔空肠和回肠体内水、电解质及钙通量的影响。家兔被分为四组：（1）静脉注射生理盐水，同时用无糖等渗盐溶液灌注空肠和回肠；（2）静脉注射降钙素，同时使用与第1组相同的肠灌注液；（3）静脉注射生理盐水，同时用10 mM葡萄糖等渗盐溶液灌注空肠和回肠；（4）静脉注射降钙素，同时肠灌注液的成分与第3组相同。在无糖和含葡萄糖的灌注液组中，降钙素均引起空肠和回肠水、钠及碳酸氢盐分泌显著增加。未观察到对钙转运有影响。这些结果与格雷等人（《临床研究杂志》52:3084 - 3088，1975年）在人体空肠中的发现相似，提示降钙素可能在约三分之一的甲状腺髓样癌患者出现的水样腹泻发病机制中起作用。此外，这些研究证明家兔作为一种动物模型，可用于进一步研究降钙素对肠液和电解质转运的影响。
