Tangrea J A, Adrianza M E, Helsel W E
Cancer Prevention Studies Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892.
Cancer Epidemiol Biomarkers Prev. 1992 May-Jun;1(4):325-30.
The perceptions of patients regarding the benefits, disadvantages, and importance of their participation in a long-term cancer chemoprevention trial, the Isotretinoin-Basal Cell Carcinoma Prevention Trial, were assessed through a questionnaire mailed at the conclusion of the 3-year treatment period of the trial. Responses were evaluated overall, as well as within subgroups defined by sex, age, education level, treatment group, presence of side effects, and the number of skin biopsies performed during the 3-year intervention phase. Overall, "careful medical follow-up received" (43%) and "being part of a research effort" (24%) were the most frequently cited important benefits, while the "amount of time taken to attend clinic" (32%) and "side effects" (20%) were the most frequently cited unpleasant aspects of trial participation. Most surveyed patients viewed the study as "very or extremely important" to their general health (62%) and their skin cancer condition (88%) and, as a result of participation, felt "much or somewhat better" physically (52%). The majority indicated that they would "definitely or probably" be willing to take part in another research study (79%) and take the study medication, if it were shown to be effective in the trial (78%). Overall and subgroup data provide important insights into patient motivations and attitudes regarding cancer chemoprevention trial participation, adherence, and satisfaction.
通过在一项长期癌症化学预防试验（异维甲酸 - 基底细胞癌预防试验）的3年治疗期结束时邮寄的问卷，评估了患者对参与该试验的益处、弊端及重要性的看法。对总体回答以及按性别、年龄、教育水平、治疗组、是否有副作用以及在3年干预阶段进行的皮肤活检数量定义的亚组回答进行了评估。总体而言，“接受仔细的医学随访”（43%）和“参与一项研究工作”（24%）是最常被提及的重要益处，而“去诊所就诊花费的时间”（32%）和“副作用”（20%）是参与试验最常被提及的不愉快方面。大多数接受调查的患者认为该研究对他们的总体健康状况“非常或极其重要”（62%）以及对他们的皮肤癌病情“非常或极其重要”（88%），并且由于参与试验，他们感觉身体“好多了或有所改善”（52%）。大多数人表示，如果该研究药物在试验中被证明有效，他们“肯定或很可能”愿意参加另一项研究（79%）并服用该研究药物（78%）。总体和亚组数据为患者参与癌症化学预防试验的动机、依从性和满意度提供了重要见解。
