Oksanen A
Horm Res. 1975;6(3):138-44. doi: 10.1159/000178671.
Diabetes was induced in adult male albino rats by a single intravenous injection of streptozotocin (75 mg/kg body weight). The diabetes was allowed to stabilize for at least 15 days, whereafter the testicular and seminal vesicle histology was studied at various time intervals. Reduction in testis weights and tubule diameters was significant after 2 weeks of diabetes. The changes in seminiferous tubules ranged from premature sloughing of epithelium to total cessation of spermatogenesis. The testicular histology of diabetic animals frequently greatly simulated the situation described following hypophysectomy. By subjective visual assessment the number of Leydig cells was found to be normal or reduced in all of the diabetic animals. Diabetes was also demonstrated to induce seminal vesicle atrophy, which did not show any correlation with the degree of testicular lesions. The possible etiology of testicular damage in diabetic animals is discussed.
通过单次静脉注射链脲佐菌素（75毫克/千克体重）诱导成年雄性白化大鼠患糖尿病。使糖尿病稳定至少15天，之后在不同时间间隔研究睾丸和精囊的组织学。糖尿病2周后，睾丸重量和小管直径的减少显著。生精小管的变化范围从上皮过早脱落到精子发生完全停止。糖尿病动物的睾丸组织学常常极大地模拟垂体切除术后所描述的情况。通过主观视觉评估发现，所有糖尿病动物的睾丸间质细胞数量正常或减少。还证明糖尿病会诱发精囊萎缩，精囊萎缩与睾丸病变程度无任何相关性。讨论了糖尿病动物睾丸损伤的可能病因。
