Anderson J E, Thliveris J A
Anat Rec. 1986 Apr;214(4):378-82. doi: 10.1002/ar.1092140407.
The use of the streptozotocin rat model for diabetes has been questioned by the appearance of extrapancreatic cytotoxicity, notably renal and hepatic. In this study the model was made specific to diabetic, drug-induced, and starvation effects on parameters of testicular histology. Formulation of orthogonal contrast expressions permitted the statistical separation of these influences. Tubules from moderately diabetic animals showed frequent thinning, and premature desquamation of pachytene spermatocytes and early spermatids from the germinal epithelium. Results showed that only diabetes significantly decreased seminiferous tubule diameter and increased testicular blood vessel numbers. In addition, significant alteration from the control pattern of tubule stage distribution was noted, particularly at stages IX-XI. Due to the inclusion of a drug-treated but nondiabetic group, streptozotocin itself was shown to have no significant effect on these parameters.
链脲佐菌素诱导的大鼠糖尿病模型因出现胰腺外细胞毒性（尤其是肾毒性和肝毒性）而受到质疑。在本研究中，该模型针对糖尿病、药物诱导及饥饿对睾丸组织学参数的影响进行了特异性构建。正交对比表达式的制定使得这些影响能够进行统计学分离。中度糖尿病动物的肾小管常出现变薄，生发上皮中的粗线期精母细胞和早期精子细胞过早脱落。结果表明，只有糖尿病会显著降低曲细精管直径并增加睾丸血管数量。此外，还注意到曲细精管阶段分布的对照模式有显著改变，特别是在IX - XI阶段。由于纳入了药物治疗但非糖尿病的组，结果显示链脲佐菌素本身对这些参数没有显著影响。
