苯对人体脂质过氧化及相关酶活性的影响
[Effects of benzene on lipid peroxidation and the activity of relevant enzymes in human].
作者信息
Chen Y Y
机构信息
Department of Labour Hygiene and Occupational Diseases, Guangdong Medical and Pharmaceutical College, Guangzhou.
出版信息
Zhonghua Yu Fang Yi Xue Za Zhi. 1992 Nov;26(6):336-8.
Lipid peroxidation and the activity of relevant enzymes in workers exposed to benzene were measured. The results indicated that the content of serum malondialdehyde (MDA) increased while the activity of erythrocyte superoxide dismutase (SOD) and erythrocyte glutathione peroxidase (GSH-Px) decreased. The above changes were statistically significant as compared with the control group when the concentration of air benzene in the working environment was 50.21 mg/m3 and became more obvious with the increase of the concentration of air benzene. These changes occurred earlier, and more sensitively reflected the effect of benzene on human beings than changes of leukocyte and platelet counts.
对接触苯的工人的脂质过氧化及相关酶活性进行了测定。结果表明，血清丙二醛（MDA）含量升高，而红细胞超氧化物歧化酶（SOD）和红细胞谷胱甘肽过氧化物酶（GSH-Px）活性降低。当工作环境中空气苯浓度为50.21mg/m³时，上述变化与对照组相比有统计学意义，且随空气苯浓度升高而更明显。这些变化出现较早，比白细胞和血小板计数的变化更敏感地反映了苯对人体的影响。
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