• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase.

作者信息

Barton G J, Ponting C P, Spraggon G, Finnis C, Sleep D

机构信息

Laboratory of Molecular Biophysics, University of Oxford, UK.

出版信息

Protein Sci. 1992 May;1(5):688-90. doi: 10.1002/pro.5560010514.

DOI:10.1002/pro.5560010514
PMID:1304367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2142224/
Abstract
摘要

相似文献

1
Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase.人血小板衍生的内皮细胞生长因子与大肠杆菌胸苷磷酸化酶同源。
Protein Sci. 1992 May;1(5):688-90. doi: 10.1002/pro.5560010514.
2
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.血小板衍生的内皮细胞生长因子具有胸苷磷酸化酶活性。
Biochem Biophys Res Commun. 1992 May 15;184(3):1311-6. doi: 10.1016/s0006-291x(05)80025-7.
3
Angiogenic factor.血管生成因子。
Nature. 1992 Apr 23;356(6371):668. doi: 10.1038/356668a0.
4
Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.血小板衍生内皮细胞生长因子在大肠杆菌中的表达及其胸苷磷酸化酶活性的确认。
Biochemistry. 1992 Dec 8;31(48):12141-6. doi: 10.1021/bi00163a024.
5
Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase.胸苷磷酸化酶活性在血小板衍生内皮细胞生长因子/胸苷磷酸化酶血管生成作用中的角色。
Cancer Res. 1995 Apr 15;55(8):1687-90.
6
Overexpression of Escherichia coli genes encoding nucleoside phosphorylases in the pET/Bl21(DE3) system yields active recombinant enzymes.在pET/Bl21(DE3)系统中，编码核苷磷酸化酶的大肠杆菌基因的过表达产生了有活性的重组酶。
Protein Expr Purif. 2002 Feb;24(1):56-60. doi: 10.1006/prep.2001.1524.
7
[Comparative study of the effect of 5-bromodeoxyuridine and 5-hydroxymethyldeoxyuridine on the development of Escherichia coli auxotrophic for thymidine].[5-溴脱氧尿苷和5-羟甲基脱氧尿苷对胸苷营养缺陷型大肠杆菌生长影响的比较研究]
Rev Latinoam Microbiol. 1981 Oct-Dec;23(4):229-34.
8
Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages.
Cancer Res. 2001 Jan 15;61(2):469-73.
9
[Cloning of Bacillus subtilis 168 genes compensating for the defect in mutations for thymidine phosphorylase and uridine phosphorylase in Escherichia coli cells].[枯草芽孢杆菌168中补偿大肠杆菌细胞胸苷磷酸化酶和尿苷磷酸化酶突变缺陷的基因的克隆]
Genetika. 1983 Jun;19(6):881-7.
10
[Escherichia coli K-12 mutants for the thymidine phosphorylase structural gene that retain the anabolic function of the enzyme].[具有胸苷磷酸化酶合成代谢功能的大肠杆菌K-12胸苷磷酸化酶结构基因突变体]
Genetika. 1981;17(9):1606-17.

引用本文的文献

1
Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy.核苷酸代谢中的胸苷磷酸化酶：生理功能及其在肿瘤发生和抗癌治疗中的意义。
Front Immunol. 2025 Apr 15;16:1561560. doi: 10.3389/fimmu.2025.1561560. eCollection 2025.
2
1,3,4-Oxadiazole: An Emerging Scaffold to Inhibit the Thymidine Phosphorylase as an Anticancer Agent.1,3,4-恶二唑：作为抗癌剂抑制胸苷磷酸化酶的新兴支架。
Curr Med Chem. 2024;31(38):6227-6250. doi: 10.2174/0929867331666230712113943.
3
Developing Wound Dressings Using 2-deoxy--Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor.利用 2-脱氧-D-核糖诱导血管生成开发伤口敷料，作为刺激血管内皮生长因子产生的后门途径。
Int J Mol Sci. 2021 Oct 23;22(21):11437. doi: 10.3390/ijms222111437.
4
Safety and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase in Mitochondrial Neurogastrointestinal Encephalomyopathy.红细胞包裹的胸苷磷酸化酶治疗线粒体神经胃肠脑肌病的安全性和有效性
J Clin Med. 2019 Apr 5;8(4):457. doi: 10.3390/jcm8040457.
5
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3.胸苷磷酸化酶通过上调信号转导和转录激活因子3（STAT3）来抑制血管平滑肌细胞增殖。
Biochim Biophys Acta. 2012 Aug;1823(8):1316-23. doi: 10.1016/j.bbamcr.2012.05.025. Epub 2012 Jun 2.
6
The dual role of thymidine phosphorylase in cancer development and chemotherapy.胸苷磷酸化酶在癌症发展和化疗中的双重作用。
Med Res Rev. 2009 Nov;29(6):903-53. doi: 10.1002/med.20159.
7
The cytosol activity of thymidine phosphorylase in endometrial cancer.子宫内膜癌中胸苷磷酸化酶的胞浆活性
J Exp Clin Cancer Res. 2008 Nov 5;27(1):64. doi: 10.1186/1756-9966-27-64.
8
Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells.干扰素通过JAK-STAT依赖性转录激活和mRNA稳定作用上调人胶质母细胞瘤细胞中的胸苷磷酸化酶表达。
J Neurooncol. 2005 May;72(3):217-23. doi: 10.1007/s11060-004-3012-4.
9
Thymidine phosphorylase activity and prodrug effects in a three-dimensional model of angiogenesis: implications for the treatment of ovarian cancer.胸苷磷酸化酶活性及前体药物在三维血管生成模型中的作用：对卵巢癌治疗的意义
Am J Pathol. 1998 Nov;153(5):1573-8. doi: 10.1016/S0002-9440(10)65745-8.
10
Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis.血小板衍生内皮细胞生长因子/胸苷磷酸化酶、底物及产物在血管生成三维模型中的作用
Am J Pathol. 1998 Jun;152(6):1641-6.

本文引用的文献

1
Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase.人血小板中胸苷的分解代谢：胸苷磷酸化酶的纯化及性质
Biochim Biophys Acta. 1981 Jul 27;654(2):211-8. doi: 10.1016/0005-2787(81)90174-x.
2
Identification of common molecular subsequences.常见分子子序列的鉴定
J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.
3
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets.纯化的人胸苷磷酸化酶和完整血小板对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）及其他5-取代-2'-脱氧尿苷的磷酸解作用
Biochem Pharmacol. 1983 Dec 1;32(23):3583-90. doi: 10.1016/0006-2952(83)90307-6.
4
Characterization and partial purification of an endothelial cell growth factor from human platelets.人血小板内皮细胞生长因子的特性鉴定与部分纯化
J Clin Invest. 1984 Feb;73(2):392-6. doi: 10.1172/JCI111224.
5
Purification and properties of an endothelial cell growth factor from human platelets.人血小板内皮细胞生长因子的纯化及特性
J Biol Chem. 1987 Mar 25;262(9):4098-103.
6
A strategy for the rapid multiple alignment of protein sequences. Confidence levels from tertiary structure comparisons.一种蛋白质序列快速多重比对的策略。来自三级结构比较的置信水平。
J Mol Biol. 1987 Nov 20;198(2):327-37. doi: 10.1016/0022-2836(87)90316-0.
7
Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture.培养的正常及转化人细胞产生血小板衍生的内皮细胞生长因子。
Proc Natl Acad Sci U S A. 1989 Oct;86(19):7427-31. doi: 10.1073/pnas.86.19.7427.
8
High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum.血小板衍生内皮细胞生长因子的高效纯化：结构表征及特异性抗血清的制备
Biochemistry. 1989 Feb 21;28(4):1704-10. doi: 10.1021/bi00430a042.
9
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.血管生成活性的鉴定以及血小板衍生内皮细胞生长因子的克隆与表达。
Nature. 1989 Apr 13;338(6216):557-62. doi: 10.1038/338557a0.
10
Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.
Biochim Biophys Acta. 1990 Apr 23;1034(1):107-13. doi: 10.1016/0304-4165(90)90160-x.