Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase.
作者信息
Barton G J, Ponting C P, Spraggon G, Finnis C, Sleep D
机构信息
Laboratory of Molecular Biophysics, University of Oxford, UK.
出版信息
Protein Sci. 1992 May;1(5):688-90. doi: 10.1002/pro.5560010514.
Abstract
摘要
相似文献
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Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase.人血小板衍生的内皮细胞生长因子与大肠杆菌胸苷磷酸化酶同源。
Protein Sci. 1992 May;1(5):688-90. doi: 10.1002/pro.5560010514.
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Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.血小板衍生的内皮细胞生长因子具有胸苷磷酸化酶活性。
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Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.血小板衍生内皮细胞生长因子在大肠杆菌中的表达及其胸苷磷酸化酶活性的确认。
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Overexpression of Escherichia coli genes encoding nucleoside phosphorylases in the pET/Bl21(DE3) system yields active recombinant enzymes.在pET/Bl21(DE3)系统中，编码核苷磷酸化酶的大肠杆菌基因的过表达产生了有活性的重组酶。
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本文引用的文献
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Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase.人血小板中胸苷的分解代谢：胸苷磷酸化酶的纯化及性质
Biochim Biophys Acta. 1981 Jul 27;654(2):211-8. doi: 10.1016/0005-2787(81)90174-x.
2
Identification of common molecular subsequences.常见分子子序列的鉴定
J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.
3
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets.纯化的人胸苷磷酸化酶和完整血小板对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）及其他5-取代-2'-脱氧尿苷的磷酸解作用
Biochem Pharmacol. 1983 Dec 1;32(23):3583-90. doi: 10.1016/0006-2952(83)90307-6.
4
Characterization and partial purification of an endothelial cell growth factor from human platelets.人血小板内皮细胞生长因子的特性鉴定与部分纯化
J Clin Invest. 1984 Feb;73(2):392-6. doi: 10.1172/JCI111224.
5
Purification and properties of an endothelial cell growth factor from human platelets.人血小板内皮细胞生长因子的纯化及特性
J Biol Chem. 1987 Mar 25;262(9):4098-103.
6
A strategy for the rapid multiple alignment of protein sequences. Confidence levels from tertiary structure comparisons.一种蛋白质序列快速多重比对的策略。来自三级结构比较的置信水平。
J Mol Biol. 1987 Nov 20;198(2):327-37. doi: 10.1016/0022-2836(87)90316-0.
7
Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture.培养的正常及转化人细胞产生血小板衍生的内皮细胞生长因子。
Proc Natl Acad Sci U S A. 1989 Oct;86(19):7427-31. doi: 10.1073/pnas.86.19.7427.
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High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum.血小板衍生内皮细胞生长因子的高效纯化：结构表征及特异性抗血清的制备
Biochemistry. 1989 Feb 21;28(4):1704-10. doi: 10.1021/bi00430a042.
9
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.血管生成活性的鉴定以及血小板衍生内皮细胞生长因子的克隆与表达。
Nature. 1989 Apr 13;338(6216):557-62. doi: 10.1038/338557a0.
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Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.
Biochim Biophys Acta. 1990 Apr 23;1034(1):107-13. doi: 10.1016/0304-4165(90)90160-x.
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