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黄芪、女贞子和墨旱莲合剂对小鼠免疫功能的影响

[Effects of mixture of Astragalus membranaceus, Fructus Ligustri lucidi and Eclipta prostrata on immune function in mice].

作者信息

He J, Li Y, Wei S, Guo M, Fu W

出版信息

Hua Xi Yi Ke Da Xue Xue Bao. 1992 Sep;23(4):408-11.

PMID:1304546
Abstract

A Chinese medicine mixture containing Astragalus membranaceus, Fructus Ligustri Lucidi and Eclipta prostrata(AFE), was fed to mice 9g/kg, 20g/kg, respectively for seven days. Observe the effects of AFE on the immune function in mice. The experiment showed that the two dosages of AFE could obviously raise the conversion percentage of lymphocytes (P < 0.01) and serum IgG level (41%-47%) of the mice. The weights of the thymus and spleensed increased in the two groups compared with those in the normal control. The larger dosage of AFE could also raise activity of Adenosine Deaminase (ADA) obviously (P < 0.01). AFE turned out a resistance to the immunosuppressive effect caused by cyclophosphamide.

摘要

将含有黄芪、女贞子和墨旱莲(AFE)的中药合剂分别以9克/千克、20克/千克的剂量喂给小鼠,持续7天。观察AFE对小鼠免疫功能的影响。实验表明,两种剂量的AFE均可显著提高小鼠淋巴细胞转化百分率(P<0.01)和血清IgG水平(41%-47%)。与正常对照组相比,两组小鼠的胸腺和脾脏重量均增加。较大剂量的AFE还可显著提高腺苷脱氨酶(ADA)活性(P<0.01)。AFE对环磷酰胺所致的免疫抑制作用具有抵抗力。

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