黄芪扶正汤对免疫抑制小鼠的免疫调节作用
[Immunoregulatory effect of Huangqi Fuzhengtang on immunosuppressive mice].
作者信息
Luo Xiaoli, Yang Kan, Sun Ming
机构信息
Department of Cardiology, Third Xiangya Hospital, Changsha 410013, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Jun;34(6):555-8.
OBJECTIVE
To explore the immunoregulatory effect of Huangqi Fuzhengtang on immunosuppressive mice.
METHODS
The immunosuppressive mouse model was established by using hydrocortisone. Huangqi Fuzhengtang and Yupingfeng San apozema were given to the mice intragastrically. The contents of hemolysin, IL-2, and INF-gamma in the mouse serum and the expression of CD3(+), CD4(+), and CD8(+) in the peripheral blood lymphocytes were measured.
RESULTS
Huangqi Fuzhengtang could obviously elevate the contents of hemolysin, IL-2, INF-gamma and the ratio of CD4(+) and CD8+, which was more effective than Yupingfeng San.
CONCLUSION
Huangqi Fuzhengtang could improve the immune function in the immunosuppressive mice.
目的
探讨黄芪扶正汤对免疫抑制小鼠的免疫调节作用。
方法
采用氢化可的松建立免疫抑制小鼠模型，将黄芪扶正汤和玉屏风散煎剂灌胃给予小鼠，检测小鼠血清中溶血素、白细胞介素-2（IL-2）和γ-干扰素（INF-γ）的含量以及外周血淋巴细胞中CD3(+)、CD4(+)和CD8(+)的表达。
结果
黄芪扶正汤能明显提高溶血素、IL-2、INF-γ的含量以及CD4(+)与CD8+的比值，且效果优于玉屏风散。
结论
黄芪扶正汤可改善免疫抑制小鼠的免疫功能。
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