Institute of Genetic and Biomedical Research (IRGB), National Research Council (CNR), Milan Unit, Milan, Italy.
IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy.
Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H181-H233. doi: 10.1152/ajpheart.00562.2021. Epub 2021 Nov 19.
Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can be caused by mutations in a wide range of proteins located in different cellular compartments. The present review is based on Dr. Ju Chen's 2021 Robert M. Berne Distinguished Lectureship of the American Physiological Society Cardiovascular Section, in which he provided an overview of the current knowledge on the cardiomyopathy-associated proteins that have been studied in his laboratory. The review provides a general summary of the proteins in different compartments of cardiomyocytes associated with cardiomyopathies, with specific focus on the proteins that have been studied in Dr. Chen's laboratory.
遗传性心肌病是全球范围内导致死亡和发病的主要原因，可由位于不同细胞区室的多种蛋白的突变引起。这篇综述基于陈居恒博士 2021 年美国生理学会心血管分部罗伯特·M·伯尔尼杰出讲师的演讲，他在演讲中概述了其实验室研究的与心肌病相关的心肌病相关蛋白的现有知识。该综述概括了与心肌病相关的不同心肌细胞区室的蛋白，重点介绍了陈博士实验室研究的蛋白。
