Itoh T, Akiyama K, Hiramatsu M, Otsuki S
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Jpn J Psychiatry Neurol. 1992 Dec;46(4):957-66. doi: 10.1111/j.1440-1819.1992.tb02867.x.
Synaptosomal membrane fluidity, lipid peroxide (LPO) and cytosolic superoxide dismutase (SOD) activity were examined in various brain regions (amygdala, hippocampus, striatum and frontal cortex) of amygdala-kindled rats. At 24 h after the last seizure, a significant increase of membrane fluidity was observed in all the regions examined, whereas the LPO level was significantly decreased in the four regions with enhanced activity of cytosolic SOD. At 7 days after the last seizure, membrane fluidity was decreased only in the hippocampus. At 6 weeks after the last seizure, there were no changes in membrane fluidity between control and kindled rats. These results suggest that membrane fluidity and lipid peroxidation are modulated transiently by a kindled seizure, but not at a steady state of kindling with enduring seizure susceptibility.
在杏仁核点燃大鼠的不同脑区（杏仁核、海马体、纹状体和额叶皮质）检测了突触体膜流动性、脂质过氧化物（LPO）和胞质超氧化物歧化酶（SOD）活性。在末次发作后24小时，在所检测的所有区域均观察到膜流动性显著增加，而在胞质SOD活性增强的四个区域中LPO水平显著降低。在末次发作后7天，仅海马体中的膜流动性降低。在末次发作后6周，对照大鼠和点燃大鼠之间的膜流动性没有变化。这些结果表明，点燃发作可短暂调节膜流动性和脂质过氧化，但在具有持久发作易感性的点燃稳态时则不然。
