Abe E, Arai M
Department of Orthopedic Surgery, Akita University School of Medicine, Japan.
Tohoku J Exp Med. 1992 Nov;168(3):499-505. doi: 10.1620/tjem.168.499.
Synovial fluid ferritin levels in patients with traumatic hemarthrosis (HA), rheumatoid arthritis (RA), and osteoarthritis (OA) were measured by double antibody radioimmunoassay. Synovial fluid ferritin levels were significantly higher in 60 patients with HA (mean +/- S.D., 536 +/- 536 ng/ml) and 39 patients with RA (614 +/- 486 ng/ml) than in 20 patients with OA (130 +/- 119 ng/ml) (p < 0.01). Individual levels, however, considerably varied. In HA patients, the synovial fluid ferritin level correlated well with the duration of hemarthrosis, but not with hemoglobin, hematocrit, or an inflammatory synovial fluid index such as the leukocyte count. In RA patients, there was no significant correlation between the synovial fluid ferritin levels and any inflammatory parameter, such as catalase activity, synovial leukocyte counts (including polymorphs and monocytes) or the duration of arthritis. Our results indicate that the synovial fluid ferritin level reflects primarily hemoglobin degradation and appears unrelated to inflammation in joint diseases.
采用双抗体放射免疫分析法测定创伤性关节积血（HA）、类风湿关节炎（RA）和骨关节炎（OA）患者的滑液铁蛋白水平。60例HA患者（均值±标准差，536±536 ng/ml）和39例RA患者（614±486 ng/ml）的滑液铁蛋白水平显著高于20例OA患者（130±119 ng/ml）（p<0.01）。然而，个体水平差异很大。在HA患者中，滑液铁蛋白水平与关节积血持续时间密切相关，但与血红蛋白、血细胞比容或炎症滑液指标如白细胞计数无关。在RA患者中，滑液铁蛋白水平与任何炎症参数之间均无显著相关性，如过氧化氢酶活性、滑液白细胞计数（包括多形核细胞和单核细胞）或关节炎持续时间。我们的结果表明，滑液铁蛋白水平主要反映血红蛋白降解，似乎与关节疾病中的炎症无关。
