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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Guimarães-Filho S R, Simal C J, Almeida H G

Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Braz J Med Biol Res. 1992;25(1):67-73.

A comparative study of the inhibitory action of topically applied indomethacin and aspirin (1% (w/v) 2 h before and immediately after trauma, totaling 4 mg each) on myosis, increase in intraocular pressure and breakdown of the blood aqueous barrier was performed. 2. Argon laser photocoagulation on the anterior surface of the left iris of pigmented rabbits, totaling 2,250 mJ, was used as traumatic stimulus. The untraumatized eye was used as a reference for measurements. 3. Four groups of 10 animals each (control, photocoagulated, photocoagulated plus indomethacin and photocoagulated plus aspirin) were studied. 4. Both drugs similarly inhibited the increase in the total protein concentration in aqueous humor and in intraocular pressure at 10, 20 and 40 min. Only aspirin showed some inhibitory action on the pupillary response 10 min after photocoagulation.

进行了一项比较研究，观察局部应用吲哚美辛和阿司匹林（创伤前2小时及创伤后立即应用1%（w/v），各4毫克）对瞳孔缩小、眼压升高和血-房水屏障破坏的抑制作用。2. 对有色家兔的左眼虹膜前表面进行氩激光光凝，总量为2250毫焦，作为创伤刺激。未受创伤的眼睛用作测量的对照。3. 研究了四组动物，每组10只（对照组、光凝组、光凝加吲哚美辛组和光凝加阿司匹林组）。4. 两种药物在10、20和40分钟时均类似地抑制房水中总蛋白浓度和眼压的升高。只有阿司匹林在光凝后10分钟对瞳孔反应有一定的抑制作用。

Guimarães-Filho S R, Simal C J, Almeida H G

Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Braz J Med Biol Res. 1992;25(1):67-73.

A comparative study of the inhibitory action of topically applied indomethacin and aspirin (1% (w/v) 2 h before and immediately after trauma, totaling 4 mg each) on myosis, increase in intraocular pressure and breakdown of the blood aqueous barrier was performed. 2. Argon laser photocoagulation on the anterior surface of the left iris of pigmented rabbits, totaling 2,250 mJ, was used as traumatic stimulus. The untraumatized eye was used as a reference for measurements. 3. Four groups of 10 animals each (control, photocoagulated, photocoagulated plus indomethacin and photocoagulated plus aspirin) were studied. 4. Both drugs similarly inhibited the increase in the total protein concentration in aqueous humor and in intraocular pressure at 10, 20 and 40 min. Only aspirin showed some inhibitory action on the pupillary response 10 min after photocoagulation.

进行了一项比较研究，观察局部应用吲哚美辛和阿司匹林（创伤前2小时及创伤后立即应用1%（w/v），各4毫克）对瞳孔缩小、眼压升高和血-房水屏障破坏的抑制作用。2. 对有色家兔的左眼虹膜前表面进行氩激光光凝，总量为2250毫焦，作为创伤刺激。未受创伤的眼睛用作测量的对照。3. 研究了四组动物，每组10只（对照组、光凝组、光凝加吲哚美辛组和光凝加阿司匹林组）。4. 两种药物在10、20和40分钟时均类似地抑制房水中总蛋白浓度和眼压的升高。只有阿司匹林在光凝后10分钟对瞳孔反应有一定的抑制作用。