Ciosek J, Guzek J W
Department of Pathophysiology, University School of Medicine, Lòdz/Poland.
Exp Clin Endocrinol. 1992;100(3):152-9. doi: 10.1055/s-0029-1211197.
Rats euhydrated and dehydrated for two or four days were given intracerebroventricularly (i.c.v.) thyrotropin-releasing hormone (TRH) in a daily dose of 200 ng dissolved in 10 microliters of 0.9% sodium chloride.) A single dose of TRH administered to euhydrated animals was followed by a significant increase of the vasopressin content in the neurohypophysis and hypothalamus as well as of the hypothalamic oxytocin content. On the contrary, a single dose of TRH decreased the oxytocin content in the neurohypophysis. Under conditions of dehydration TRH distinctly restrained the decrease of vasopressin and oxytocin in the hypothalamus. In animals dehydrated for two or four days the decrease of oxytocin in the neurohypophysis, brought about by stimulation of osmoreceptors, was distinctly more marked under treatment with TRH. On the contrary, the depletion of neurohypophysial vasopressin was significantly less apparent under such conditions. 28 nmol/L TRH markedly increased vasopressin release but inhibited that of oxytocin from the neurointermediate lobes incubated in vitro both under basal conditions as well as during stimulation with excess (56 mmol) potassium.
将正常水合及脱水2天或4天的大鼠，通过脑室内注射（i.c.v.）促甲状腺激素释放激素（TRH），每日剂量为200 ng，溶于10微升0.9%氯化钠溶液中。给正常水合动物单次注射TRH后，神经垂体和下丘脑的血管加压素含量以及下丘脑的催产素含量显著增加。相反，单次注射TRH会降低神经垂体中的催产素含量。在脱水状态下，TRH明显抑制下丘脑血管加压素和催产素的减少。在脱水2天或4天的动物中，由渗透压感受器刺激引起的神经垂体中催产素的减少，在TRH治疗下明显更为显著。相反，在这种情况下，神经垂体血管加压素的消耗明显不那么明显。28 nmol/L的TRH在基础条件下以及在用过量（56 mmol）钾刺激期间，均显著增加血管加压素的释放，但抑制了来自体外培养的神经中间叶的催产素释放。
