Ciosek J, Guzek J W, Orłowska-Majdak M
Department of Pathophysiology, University School of Medicine, Lódź, Poland.
J Physiol Pharmacol. 1993 Sep;44(3):293-302.
Rats euhydrated and dehydrated during two or four days were given intracerebroventricularly (i.c.v.) thyrotropin-releasing hormone (TRH) in a daily dose of 200 ng dissolved in 10 microliters of 0.9% sodium chloride. A single dose of TRH injected to euhydrated animals increased the hypothalamic vasopressin content but did not affect significantly the content of vasopressin in the neurohypophysis as well as that of oxytocin both in the hypothalamus and neurohypophysis. In rats deprived of water for two days TRH completely prevented the decrease of neurohypophysial oxytocin due to stimulation of osmoreceptor origin. Similarly, TRH restrained both the hypothalamic and the neurohypophysial vasopressin and oxytocin depletion in rats dehydrated for four days.
对在两天或四天内处于正常水合状态和脱水状态的大鼠，每天经脑室内（i.c.v.）给予溶解于10微升0.9%氯化钠中的200纳克促甲状腺激素释放激素（TRH）。向正常水合的动物注射单剂量的TRH可增加下丘脑抗利尿激素含量，但对神经垂体中抗利尿激素的含量以及下丘脑和神经垂体中催产素的含量均无显著影响。在缺水两天的大鼠中，TRH完全阻止了因渗透压感受器受刺激而导致的神经垂体催产素的减少。同样，TRH抑制了脱水四天的大鼠下丘脑和神经垂体中抗利尿激素和催产素的消耗。
