Ciosek J
Department of Pathophysiology, University School of Medicine, Lódź.
Patol Pol. 1993;44(4):221-6.
Rats drinking and libitum tap water or hypertonic (i.e., 2%) sodium chloride solution were given intracerebroventricularly (i.c.v.), during three days, thyrotropin-releasing hormone (TRH) in a daily dose of 200 ng dissolved in 10 microliters of 0.9% sodium chloride. Treatment with TRH resulted in significantly increased hypothalamic oxytocin content in both euhydrated (i.e., given tap water ad libitum) and salt-loaded rats and vasopressin content only in euhydrated rats. Similarly, neurohypophysial vasopressin and oxytocin content significantly increased in animals drinking tap water or 2% sodium chloride during treatment with TRH. The present data suggest that TRH may be involved in some regulatory processes to vasopressin and oxytocin biosynthesis and release from the rat hypothalamo-neurohypophysial system.
给自由饮用自来水或高渗（即2%）氯化钠溶液的大鼠，在三天内每天经脑室内（i.c.v.）给予溶解于10微升0.9%氯化钠中的促甲状腺激素释放激素（TRH），剂量为每日200纳克。TRH处理导致正常水合状态（即自由给予自来水）和盐负荷大鼠的下丘脑催产素含量均显著增加，而仅在正常水合状态大鼠中血管加压素含量增加。同样，在用TRH处理期间，饮用自来水或2%氯化钠的动物神经垂体血管加压素和催产素含量显著增加。目前的数据表明，TRH可能参与大鼠下丘脑 - 神经垂体系统中血管加压素和催产素生物合成及释放的某些调节过程。
