Dragani L, D'Aurelio A, Vecchiet L
Cattedra di Semeiotica Medica, Università degli Studi G. D'Annunzio, Chieti.
Riv Eur Sci Med Farmacol. 1992 Jul-Aug;14(4):271-7.
We evaluated the efficacy of heparin-glucuronylglucosaminoglycane association topically used on periarticular deep tissues (subcutaneous and muscle), in 20 females divided into two homogeneous groups of 10 each, affected by painful osteoarthritis of the knee. Electrically stimulated subcutaneous and muscular pain thresholds have been assessed; ultrasound scan of subcutaneous tissue overlying articular rima and vastus medialis muscle, and ultrasound scan of vastus medialis muscle thickness have been also examined. The measurements have been done (at the beginning of the experiment) in basal conditions and respectively after one, two, and three weeks treatment with the drug or placebo administered in a double blind fashion. Subcutaneous and muscular pain thresholds have shown an important rise right from the first week of treatment; subcutaneous tissue thickness was significantly decreased after two weeks treatment and in the same period a significant increase of vastus medialis muscle was registered. No such variations have been shown after placebo treatment. The possible mechanisms of such effects have been assessed in a peripheral control action of inflammation, with decrease of nociceptive message and consequent limitation of dystrophic reflex phenomena.
我们评估了肝素-葡萄糖醛酸氨基葡聚糖组合局部用于关节周围深部组织（皮下和肌肉）的疗效，研究对象为20名女性，她们均患有膝关节疼痛性骨关节炎，被分为两组，每组10人，两组情况均一。评估了电刺激下的皮下和肌肉疼痛阈值；还检查了关节裂上方皮下组织以及股内侧肌的超声扫描情况，以及股内侧肌厚度的超声扫描情况。测量工作在（实验开始时）基础条件下进行，并在以双盲方式给予药物或安慰剂治疗1周、2周和3周后分别进行。皮下和肌肉疼痛阈值从治疗的第一周起就有显著提高；治疗两周后皮下组织厚度显著降低，且在同一时期股内侧肌有显著增厚。安慰剂治疗后未出现此类变化。已从炎症的外周控制作用方面评估了此类效应的可能机制，包括伤害性信息的减少以及随之而来的营养不良性反射现象的限制。
