Vidović A, Janković G, Suvajdzić N, Colović M
Institute of Haematology, University Clinical Centre, Belgrade.
Srp Arh Celok Lek. 1992 Sep-Oct;120(9-10):304-5.
A patient with Ph1(Philadelphia chromosome) positive chronic granulocytic leukemia and extramedullary blast transformation (crisis) in lymph nodes of neck and axillae which appeared after 4-year of treatment with busulfan is presented. Biopsy of lymph node and histopathological examination showed lymphoblastic infiltration. The patient was treated with radiotherapy and chemotherapy with protocol COP. He survived 7 months and expired due to renal insufficiency.
本文报告1例慢性粒细胞白血病（CML）患者，该患者Ph1（费城染色体）阳性，在用白消安治疗4年后出现颈部和腋窝淋巴结髓外原始细胞转化（急变期）。淋巴结活检及组织病理学检查显示为淋巴细胞母细胞浸润。患者接受了COP方案的放疗和化疗。患者存活7个月，最终因肾功能不全死亡。
