Casley-Smith J R
Henry Thomas Laboratory, University of Adelaide, Australia.
Biorheology. 1992 Sep-Dec;29(5-6):535-48. doi: 10.3233/bir-1992-295-613.
A mathematical model has been constructed to investigate the alterations, in amount and in importance, of the Factors controlling interstitial fluid volume in a number of steady-state oedemas. There are many so-called "Safety Factors" (at least 15), including a whole group concerned with regulating the amount of protein in the tissues (and thus tissue colloidal osmotic pressure). They are often in long hierarchies (of even up to 11 Factors), each influencing the next. Sometimes a Factor is recursive, i.e., it influences itself (either positively or negatively) via a Hierarchy of other Factors. The effects of some Factors differ in different Hierarchies, i.e., an increase in the Factor will increase VI via some of the Hierarchies and decrease it via some other Hierarchies. Which effect is most important varies with the Hierarchies and conditions existing at the time. The Factors are best compared if expressed in the same units: ml/min/100g of tissue. This is possible via appropriate multiplication factors derived from the relevant equations.
已经构建了一个数学模型，以研究在多种稳态水肿中，控制组织间液量的因素在数量和重要性方面的变化。存在许多所谓的“安全因素”（至少15个），包括一整套与调节组织中蛋白质含量（进而调节组织胶体渗透压）有关的因素。它们常常处于长层级结构中（甚至多达11个因素），每个因素影响下一个因素。有时一个因素是递归的，即它通过其他因素的层级结构对自身产生影响（无论是正向还是负向）。某些因素在不同层级结构中的作用不同，也就是说，该因素的增加会通过某些层级结构增加组织间液量，而通过其他一些层级结构减少组织间液量。哪种作用最重要，会因当时存在的层级结构和条件而异。如果将这些因素用相同的单位表示：毫升/分钟/100克组织，那么它们之间的比较最为合适。这可以通过从相关方程中推导出来的适当乘法因子来实现。
