Casley-Smith J R
Henry Thomas Laboratory, University of Adelaide, Australia.
Biorheology. 1993 Jan-Feb;30(1):9-30.
A mathematical model has been used to investigate the alterations, in amount and importance, of the Factors controlling interstitial fluid volume in a number of steady-state oedemas. Steady-states were used because it is much easier to evaluate the effect of a specific Factor on oedema if all the others are constant. They are best compared if expressed in the same units: ml/min/100 g of tissue. The effects of lymphatic drainage on trauma are very important, as is the effect of tissue proteolysis on lymphoedema. Tissue proteolysis has minimal effects on the normal state and trauma; yet modelling its increase with benzo-pyrones markedly reduces oedema in both trauma and lymphoedema. Excess fibrosis greatly reduces lymphoedema. The effects of the individual Factors vary considerably between the different steady-states.
一个数学模型已被用于研究在一些稳态水肿中控制组织间液量的因素在数量和重要性方面的变化。使用稳态是因为如果所有其他因素都保持不变，那么评估特定因素对水肿的影响会容易得多。如果以相同的单位（毫升/分钟/100克组织）来表示，它们会更便于比较。淋巴引流对创伤的影响非常重要，组织蛋白水解对淋巴水肿的影响同样重要。组织蛋白水解对正常状态和创伤的影响极小；然而，模拟其因苯并芘而增加的情况会显著减轻创伤和淋巴水肿中的水肿。过度纤维化会大大减轻淋巴水肿。不同稳态下各个因素的影响差异很大。
