Takeuchi Y, Yokota Y, Tsumura Y, Nakatani M, Kawai H, Shite J, Fukuzaki H
First Department of Internal Medicine, Kobe University School of Medicine.
J Cardiol. 1992;22(1):193-200.
To investigate the left atrial ejection performance in heart failure, we observed both the transmitral (TMF) and pulmonary venous flow waves (PVF) by transesophageal Doppler echocardiography in 20 patients with heart failure (16 males, 4 females, 56 +/- 13 years old). In 7 of 20 patients, pulmonary capillary wedge pressures (PC) were also obtained within 72 hours after the transesophageal Doppler echocardiographic examinations. A reversal flow on PVF during atrial systole (atrial backward ejection flow) was observed in all of the 20 patients. Corrected atrial pre-ejection period correlated significantly with PC (r = -0.76, p < 0.05), indicating that the period was shortened in accordance with left atrial Starling's law. This period correlated significantly with both the duration and the time velocity integral of atrial backward flow (r = -0.72, p < 0.005; r = -0.55, p < 0.05, respectively), but not with the atrial ejection time nor with the time velocity integral of atrial systole. These results suggest that in some cases of heart failure, left atrial contractile function is preserved despite the marked augmentation of left atrial afterload, resulting in a decrease of the left atrial forward ejection and an increase of the left atrial backward ejection. Thus, the observations of TMF and PVF by transesophageal Doppler echocardiography are useful for assessing the left atrial ejection performance in patients with heart failure.
为研究心力衰竭时左心房射血功能,我们采用经食管多普勒超声心动图观察了20例心力衰竭患者(男16例,女4例,年龄56±13岁)的二尖瓣血流频谱(TMF)和肺静脉血流频谱(PVF)。20例患者中有7例在经食管多普勒超声心动图检查后72小时内还测定了肺毛细血管楔压(PC)。所有20例患者均观察到心房收缩期肺静脉血流频谱出现逆向血流(心房逆向射血血流)。校正后的心房射血前期与PC显著相关(r = -0.76,p < 0.05),表明该时期根据左心房的Starling定律缩短。该时期与心房逆向血流的持续时间和时间速度积分均显著相关(分别为r = -0.72,p < 0.005;r = -0.55,p < 0.05),但与心房射血时间及心房收缩期的时间速度积分无关。这些结果提示,在某些心力衰竭病例中,尽管左心房后负荷显著增加,但左心房收缩功能仍得以保留,导致左心房前向射血减少,左心房逆向射血增加。因此,经食管多普勒超声心动图观察TMF和PVF有助于评估心力衰竭患者的左心房射血功能。