Papa C M
Acta Derm Venereol Suppl (Stockh). 1975;74:128-32.
Topical tretinoin is a valuable therapeutic agent whose chief drawback has been local primary irritation. What were thought to be special difficulties with photosensitivity reactions and pigmentary changes in dark skin, really turn out to be other manifestations of the irritancy. Advances in the development of newer dosage forms and treatment regimens, together with expanded knowledge of the many factors which contribute to the problem, mean that there should be very few patients who cannot be treated with tretinoin. Only the rare patient with true hypersensitivity to the drug need be denied. Appropriate therapy still requires a modicum of personal attention to the individual patient's needs-but that is what the practice of medicine is all about.
外用维甲酸是一种有价值的治疗药物，其主要缺点是局部原发性刺激。过去认为在深色皮肤中光敏反应和色素变化存在特殊困难，实际上这些都是刺激的其他表现形式。新型剂型和治疗方案的开发取得进展，以及对导致该问题的多种因素的认识不断扩大，这意味着几乎没有患者不能用维甲酸治疗。只有极少数对该药物真正过敏的患者才需要排除在外。适当的治疗仍需要对个体患者的需求给予一定的关注——但这正是医学实践的意义所在。
