Plewig G, Braun-Falco O
Acta Derm Venereol Suppl (Stockh). 1975;74:87-98.
The effects of topically applied vitamin A acid and benzoyl peroxide were investigated. Short-term (a few days) and long-term (up to 800 days) treatment was analyzed histologically and autoradiographically. Labelled and unlabelled biopsies at various time intervals were taken from face, back, and acne lesions. Kinetics were followed with 3H-TdR and 3H-histidine. All keratinizing epithelia of epidermis and adnexa are stimulated by vitamin A acid. Labelling is high (up to 20-70% L.I) and occurs within a few days. Follicles and comedones can also be stimulated, but respond less and much later than epidermis. Transit time is shortened to 3-4 days. Lose, incoherent horny cells are produced, explaining the therapeutic benefits of vitamin A acid in acne. Benzoyl peroxide is less effective in stimulating epidermopoieses in epidermis, follicles, and comedones. This autoradiographic analysis parallels therapeutic results with these two exfoliants.
研究了局部应用维甲酸和过氧化苯甲酰的效果。对短期（几天）和长期（长达800天）治疗进行了组织学和放射自显影分析。在不同时间间隔从面部、背部和痤疮损害处采集标记和未标记的活检组织。用³H-胸腺嘧啶核苷和³H-组氨酸追踪动力学。维甲酸可刺激表皮和附属器的所有角质形成上皮。标记率很高（高达20%-70%标记指数），且在几天内出现。毛囊和粉刺也可被刺激，但反应比表皮少且晚得多。转运时间缩短至3-4天。产生松散、不连贯的角质细胞，这解释了维甲酸治疗痤疮的益处。过氧化苯甲酰在刺激表皮、毛囊和粉刺的表皮形成方面效果较差。这种放射自显影分析与这两种剥脱剂的治疗结果相似。
