Pereira J S, Bertolucci P H, Ferraz H B, De Andrade L A
Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Brasli.
Arq Neuropsiquiatr. 1992 Sep;50(3):263-8. doi: 10.1590/s0004-282x1992000300001.
Tardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphine was rated. The CCB drugs were administered in acute (in the 28th day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.
迟发性运动障碍（TD）是长期使用抗精神病药物引起的一种严重并发症，目前尚无有效的治疗方法。我们进行了一项实验，研究钙通道阻滞剂（CCB）药物维拉帕米和氟桂利嗪对TD的作用。我们通过给大鼠连续21天服用氟哌啶醇建立了TD模型。此后，对阿扑吗啡诱导的刻板运动进行评分。在急性实验（第28天）和慢性实验（第25天后持续8天）中给予CCB药物。急性给药时，维拉帕米增加了刻板行为，而在慢性实验中则促进了刻板行为的减少。结果表明，CCB药物应在TD的临床试验中进行测试。
