Arenas-Huertero F, Salazar Flores M, Pasquel-García P
Departamento de Patología, Instituto Nacional de Enfermedades Respiratorias, México, D.F.
Arch Med Res. 1992 Winter;23(4):169-75.
In this study we evaluated the usefulness of ferruginous bodies (FB) quantification in lung digest and histologic sections from 40 patients with a history of exposure to inorganic dusts. The patients were matched with 40 cases without occupational exposure. The samples of peripheral lung tissue were digested and all FB were quantified. Lung sections were also evaluated in order to confirm the presence of FB. The concentrations of FB in the patients were higher than the controls (Wilcoxon test, p < 0.001). The patients group showed a median concentration of 194.5 FB/g of dry lung tissue (FB/g) vs. 34.0 FB/g in the controls. Seventy percent of the patients had more than 100 FB/g vs. 27.5% in the controls cases. Pneumoconiosis was diagnosed in 19 patients, 17 had FB/g above 100 and only 4 were positive to FB in lung sections. We can conclude that lung digest and FB counts help to confirm exposures to inorganic dusts above the background values found in the general population. FB counts can help when the clinical file does not confirm the exposure.
在本研究中，我们评估了对40例有接触无机粉尘史患者的肺消化物和组织切片中铁质小体（FB）定量分析的作用。这些患者与40例无职业暴露的病例进行匹配。对周围肺组织样本进行消化，并对所有FB进行定量分析。同时对肺切片进行评估以确认FB的存在。患者组中FB的浓度高于对照组（Wilcoxon检验，p<0.001）。患者组的干肺组织中FB的中位浓度为194.5个FB/g，而对照组为34.0个FB/g。70%的患者FB/g超过100，而对照组病例为27.5%。19例患者被诊断为尘肺，其中17例FB/g高于100，只有4例肺切片中FB呈阳性。我们可以得出结论，肺消化物和FB计数有助于确认接触无机粉尘的情况超过了一般人群中的背景值。当临床档案不能证实暴露情况时，FB计数会有所帮助。
