Jabłonka S, Ledwozyw A, Kadziołka W, Jabłonka A, Nestorowicz A
Department of Thoracic and Cardiac Surgery, Medical Academy, Lublin, Poland.
Arch Vet Pol. 1992;32(1-2):57-66.
The purpose of the studies was to determine the effect of Ambroxol on the activity of antioxidant enzymes and on the glutathione level as well as the intensity of the peroxidative processes in the lung tissue, alveolar macrophages and plasma in dogs after unilateral pulmonectomy. On the 2nd and 6th day after the surgery the activity of antioxidant enzymes and the glutathione level were studied in the remaining lung. The levels of the lipid peroxidation products were determined in the analogous system. In both examined groups the increase in the antioxidant enzyme activity and the lipid peroxidation product levels was observed in the remaining lung after the surgery. In Ambroxol-treated animals the statistically significant increase in the antioxidant enzyme activity was noted while the intensity of peroxidative processes was found to be lower. This fact may suggest that Ambroxol stimulates the resistance of the lung tissue to the free radical activity and inhibits the lung peroxidative processes in dogs after pulmonectomy.
这些研究的目的是确定氨溴索对单侧肺切除术后犬肺组织、肺泡巨噬细胞和血浆中抗氧化酶活性、谷胱甘肽水平以及过氧化过程强度的影响。在手术后第2天和第6天，对剩余肺组织中的抗氧化酶活性和谷胱甘肽水平进行了研究。在类似系统中测定脂质过氧化产物的水平。在两个研究组中，术后剩余肺组织中均观察到抗氧化酶活性和脂质过氧化产物水平升高。在接受氨溴索治疗的动物中，抗氧化酶活性有统计学意义的增加，而过氧化过程的强度较低。这一事实可能表明，氨溴索可刺激犬肺组织对自由基活性的抵抗力，并抑制肺切除术后犬的肺过氧化过程。
