Nowak D, Pietras T, Antczak A, Król M, Piasecka G
Department of Pneumonology and Allergology, Medical Academy, Lódź, Poland.
Pol J Pharmacol. 1993 May-Jun;45(3):317-22.
Administration of ambroxol (70 mg/kg ip) once a day for 3 days protected lung and heart lipids from lipopolysaccharide (LPS, 17 mg/kg)-induced oxidative stress in mice. Ambroxol as a lipid peroxidation inhibitor was almost as active as an equivalent dose of N-acetylcysteine (27.6 mg/kg), a well known antioxidant. The lung and heart levels of conjugated dienes in animals pretreated with ambroxol were 3.3- and 1.7-times lower (p < 0.05 and p < 0.01) than those observed in the control group which received only buffer and subsequently LPS. These results indicate that ambroxol can sufficiently inhibit the harmful process of lipid peroxidation in vivo.
每天腹腔注射氨溴索（70毫克/千克），连续3天，可保护小鼠肺和心脏脂质免受脂多糖（LPS，17毫克/千克）诱导的氧化应激。氨溴索作为脂质过氧化抑制剂，其活性几乎与等效剂量的N-乙酰半胱氨酸（27.6毫克/千克，一种著名的抗氧化剂）相当。用氨溴索预处理的动物肺和心脏中共轭二烯水平比仅接受缓冲液随后接受LPS的对照组低3.3倍和1.7倍（p < 0.05和p < 0.01）。这些结果表明，氨溴索可充分抑制体内脂质过氧化的有害过程。
