Nemes Z
Department of Pathology, University Medical School of Debrecen, Hungary.
Cancer. 1992 Jan 1;69(1):133-40. doi: 10.1002/1097-0142(19920101)69:1<133::aid-cncr2820690124>3.0.co;2-#.
Normal pericytes were found to express factor XIIIa (F-XIII) and histocompatibility antigen HLA-DR. These markers were studied in 15 hemangiopericytomas (HPC) and 16 other tumors with an HPC-like pattern. A subpopulation of tumor cells expressing F-XIII and HLA-DR antigens was a constant feature of HPC and supported their pericytic origin. Meningeal HPC did not differ in phenotype from peripheral soft tissue HPC. Most tumors with an HPC-like pattern (including synovial sarcomas, malignant schwannomas, leiomyosarcomas, and liposarcomas) were negative for F-XIII and HLA-DR. Malignant fibrous histiocytomas, however, invariably contained a subpopulation expressing these antigens. Therefore, F-XIII can be considered as a marker of fibrohistiocytic differentiation in HPC. Individual tumor cells in HPC occasionally were positive for factor VIII-related antigen (F-VIII-R-Ag), suggesting that the spectrum of differentiation in HPC may include the endothelial cell line. The differentiation characteristics of HPC support the concept that pericytes are primitive cells that may act as precursors to other mesenchymal cells.
研究发现，正常周细胞表达因子ⅩⅢa（F-ⅩⅢ）和组织相容性抗原HLA-DR。对15例血管外皮细胞瘤（HPC）和16例具有HPC样形态的其他肿瘤进行了这些标志物的研究。表达F-ⅩⅢ和HLA-DR抗原的肿瘤细胞亚群是HPC的一个恒定特征，支持其周细胞起源。脑膜HPC与外周软组织HPC在表型上无差异。大多数具有HPC样形态的肿瘤（包括滑膜肉瘤、恶性神经鞘瘤、平滑肌肉瘤和脂肪肉瘤）F-ⅩⅢ和HLA-DR呈阴性。然而，恶性纤维组织细胞瘤总是含有表达这些抗原的亚群。因此，F-ⅩⅢ可被视为HPC中纤维组织细胞分化的标志物。HPC中的个别肿瘤细胞偶尔对因子Ⅷ相关抗原（F-Ⅷ-R-Ag）呈阳性，提示HPC的分化谱可能包括内皮细胞系。HPC的分化特征支持周细胞是原始细胞，可能作为其他间充质细胞前体的概念。
