慢性非甲非乙型肝病中丙型肝炎病毒RNA的检测
Detection of hepatitis C virus RNA in chronic non-A, non-B liver disease.
作者信息
Hagiwara H, Hayashi N, Mita E, Hiramatsu N, Ueda K, Takehara T, Yuki N, Kasahara A, Fusamoto H, Kamada T
机构信息
First Department of Medicine, Osaka University Medical School, Japan.
出版信息
Gastroenterology. 1992 Feb;102(2):692-4. doi: 10.1016/0016-5085(92)90122-f.
Serum samples were tested for detection of hepatitis C virus (HCV) RNA from 156 patients with chronic non-A, non-B liver disease. HCV RNA was detected in 121 (93.8%) of 129 patients positive for anti-C100-3 but was also found in 15 (55.6%) of 27 patients negative for anti-C100-3. The rate of positivity for HCV RNA was not significantly different among various stages of liver diseases. These results showed that HCV continues to replicate even in advanced liver disease and that it seems to be related to half of the cases of chronic non-A, non-B liver disease negative for anti-C100-3.
对156例慢性非甲非乙型肝病患者的血清样本进行检测，以检测丙型肝炎病毒（HCV）RNA。在129例抗C100-3阳性的患者中，有121例（93.8%）检测到HCV RNA，但在27例抗C100-3阴性的患者中，也有15例（55.6%）检测到HCV RNA。HCV RNA的阳性率在肝病的不同阶段之间没有显著差异。这些结果表明，即使在晚期肝病中，HCV仍在继续复制，而且它似乎与一半的抗C100-3阴性的慢性非甲非乙型肝病病例有关。
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