用于检测抗丙型肝炎病毒（HCV）抗体的第三代检测方法的评估以及与对c100-3抗原呈反应性的献血者血液中HCV RNA存在情况的比较。
Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen.
作者信息
Lavanchy D, Mayerat C, Morel B, Schneider P, Zufferey C, Gonvers J J, Pécoud A, Frei P C
机构信息
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
出版信息
J Clin Microbiol. 1994 Sep;32(9):2272-5. doi: 10.1128/jcm.32.9.2272-2275.1994.
Abstract
We tested serum samples from blood donors by using first-, second-, and third-generation enzyme immunoassays or recombinant immunoblot assays. Second- and third-generation assays gave comparable results. Circulating hepatitis C virus RNA was found in a high proportion of reactive samples. A lack of reactivity or low-level reactivity predicted the absence of hepatitis C virus RNA in 100% of the cases.
摘要
我们通过使用第一代、第二代和第三代酶免疫测定法或重组免疫印迹测定法对献血者的血清样本进行检测。第二代和第三代测定法给出了相似的结果。在高比例的反应性样本中发现了循环丙型肝炎病毒RNA。无反应性或低水平反应性在100%的病例中预示着不存在丙型肝炎病毒RNA。
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