Pappo O, Gez E, Craciun I, Zajicek G, Okon E
Department of Pathology, Hadassah Medical Center, Jerusalem, Israel.
Arch Pathol Lab Med. 1992 Jan;116(1):76-9.
Growth rate analysis of lung metastases of a cutaneous adenoid cystic carcinoma, which appeared 18 years after the resection of the primary tumor from the scalp is presented. The doubling times of the metastases were long compared with that of other lung metastases. They were 22 months for the metastasis in the right lung and 70 months for the metastasis in the left lung, with a shortening of the doubling time in the left side to 10.4 months in the last 4 months of observation. Backward extrapolation showed that the metastases to the lung were disseminated before the diagnosis and surgical resection of the primary tumor. To our knowledge, this is the third reported case of lung metastases from a cutaneous adenoid cystic carcinoma out of 25 documented cases. We present a review of the literature and discuss the clinical implications of our findings.
本文报告了一例皮肤腺样囊性癌肺转移的生长速率分析，该转移灶在原发肿瘤从头皮切除18年后出现。与其他肺转移灶相比，该转移灶的倍增时间较长。右肺转移灶的倍增时间为22个月，左肺转移灶的倍增时间为70个月，在观察的最后4个月，左侧转移灶的倍增时间缩短至10.4个月。反向推断显示，肺转移在原发肿瘤诊断和手术切除之前就已发生。据我们所知，这是25例有记录的病例中第三例报告的皮肤腺样囊性癌肺转移病例。我们对文献进行了综述，并讨论了我们研究结果的临床意义。
