Lélek I, Gasztonyi V
Rofo. 1976 Mar;124(3):226-32.
The authors have twice observed undesirable effects of adrenaline during the demonstration of malignant renal tumours. Following adrenaline there was less flow of contrast medium into the tumour vessels than during angiography without the drug. In their opinion, this is due to the fact that constriction of the inter-lobar arteries occludes the vessels supplying the tumour, and that in some cases the new-formed vessels react strongly to adrenaline. In a third case, the tumour vessels reacted much more strikingly to adrenaline than would have been expected from previous experience. They therefore doubt whether pharmaco-angiography with adrenaline is always indicated for demonstrating malignant renal tumours; adrenaline may be expected to produce a positive result only in these cases in which there is a central origin of the artery supplying the tumour. They therefore suggest a change to some other, more suitable drug.
作者在演示恶性肾肿瘤的过程中曾两次观察到肾上腺素的不良影响。注射肾上腺素后，与未使用该药物的血管造影相比，进入肿瘤血管的造影剂流量减少。他们认为，这是由于叶间动脉收缩阻塞了供应肿瘤的血管，并且在某些情况下，新生血管对肾上腺素反应强烈。在第三个病例中，肿瘤血管对肾上腺素的反应比以往经验预期的要强烈得多。因此，他们怀疑使用肾上腺素进行药物血管造影是否总是适用于显示恶性肾肿瘤；只有在供应肿瘤的动脉起源于中央的情况下，肾上腺素才可能产生阳性结果。因此，他们建议改用其他更合适的药物。
