Tassopoulos N C, Hatzakis A, Delladetsima I, Koutelou M G, Todoulos A, Miriagou V
First Department of Medicine, Western Attica General Hospital, Athens, Greece.
Gastroenterology. 1992 Mar;102(3):969-72. doi: 10.1016/0016-5085(92)90184-z.
The prevalence of hepatitis C virus (HCV) infection in 182 prospectively followed adult patients (110 males, 72 females) with acute non-A, non-B hepatitis and its correlation with progression to chronic hepatitis were studied. These patients were followed for a mean of 24.7 +/- 13.1 (range, 6-57) months. By using a specific enzyme immunoassay for the detection of antibodies against C100-3 polypeptide of HCV, 96 (52.7%) were found antibody positive. HCV was implicated in 64/89 (71.9%) of the cases with classical parenteral exposure but only in 18/64 (28.1%) of the community-acquired cases. Progression to chronic hepatitis was observed more frequently in antibody-positive than in antibody-negative cases (60/96 or 62.5% vs. 27/86 or 31.4%, P = 0.00002). Progression was also observed more often in males than in females (66/112 or 58.9% vs. 21/70 or 30.0% P = 0.0001), both in the antibody positive (48/68 or 70.6% vs. 12/28 or 42.9%, P = 0.01) and in the antibody negative (18/44 or 40.9% vs. 9/42 or 21.4%, P = 0.043) cases. These data indicate that (a) acute hepatitis due to HCV is characterized by a high rate of chronicity, especially in males, and (b) a non-A, non-B, non-C agent or a different strain of HCV may be responsible for the majority of the community-acquired cases of non-A, non-B hepatitis in Greece.
对182例前瞻性随访的急性非甲非乙型肝炎成年患者（110例男性，72例女性）进行丙型肝炎病毒（HCV）感染率及其与慢性肝炎进展相关性的研究。这些患者平均随访了24.7±13.1（范围6 - 57）个月。通过使用检测抗HCV C100 - 3多肽抗体的特异性酶免疫测定法，发现96例（52.7%）抗体呈阳性。在有典型肠道外暴露史的89例病例中，64例（71.9%）与HCV有关，但社区获得性病例中仅18例（28.1%）与HCV有关。抗体阳性病例比抗体阴性病例更常进展为慢性肝炎（60/96或62.5% 对27/86或31.4%，P = 0.00002）。男性比女性更常出现进展（66/112或58.9% 对21/70或30.0%，P = 0.0001），抗体阳性病例（48/68或70.6% 对12/28或42.9%，P = 0.01）和抗体阴性病例（18/44或40.9% 对9/42或21.4%，P = 0.043）均如此。这些数据表明：（a）由HCV引起的急性肝炎的特点是慢性化率高，尤其是在男性中；（b）在希腊，非甲非乙型肝炎的社区获得性病例多数可能由非甲非乙非丙型病原体或不同株的HCV引起。
