Ji Y Y, Liu Y F, Chen Z N
Department of Pathology, Fourth Military Medical University, Shaanxi, People's Republic of China.
Cancer. 1992 Apr 15;69(8):2055-9. doi: 10.1002/1097-0142(19920415)69:8<2055::aid-cncr2820690809>3.0.co;2-b.
The monoclonal antibody against human hepatocellular carcinoma, HAb23, was conjugated with radioiodine and injected into nude mice with human hepatoma xenografts. After 4 to 5 days, the nude mice were scanned by emission computerized topography. The results showed that the xenografts were distinguished clearly. The tumor-liver and tumor-blood ratios were 1.94 to 3.66 and 0.56 to 1.65, respectively. Autoradiography showed that the HAb23 was localized mainly on the surface membrane and tubulovesicular systems of the tumor cells.
将抗人肝癌单克隆抗体HAb23与放射性碘结合，然后注射到有人肝癌异种移植瘤的裸鼠体内。4至5天后，用发射型计算机断层扫描对裸鼠进行扫描。结果显示，异种移植瘤显示清晰。肿瘤与肝脏及肿瘤与血液的比值分别为1.94至3.66和0.56至1.65。放射自显影显示，HAb23主要定位在肿瘤细胞的表面膜和微管泡系统上。
