Shi L, Wu M, Chen H
Institute of Hepatobiliary Surgery, Shanghai.
Zhonghua Zhong Liu Za Zhi. 1995 Jan;17(1):20-3.
Tumor xenografts of human PHC were grown in nude mice subcutaneously. The studies were performed in nude mice with tumor base aear of 0.8cm-1.0cm. For the study of RII, the mice were injected intravenously with 1.11 x 10(7)Bq/mouse of 131I-hepama-1. All tumours were clearly visualied on the 4th day after injection and remained the same until the 7th day. No tumor image was found in 131I-mIgG. The tumor to liver ratio of radioactivity increased from 1.3 to 3.03 in 131I-Hepama-1 group, but decreased from 13.6 to 6.88% in 131I-mIgG group. For the study of RIT 131I-hepama-1 (1.85 x 10(10)Bq) was administered intraperitoneally. A tumor growth inhibition rate at the 4th week after the infusion of 70.5% was obtained. The median survival time of the nude mice in 131I-hepama-1 group was much longer than in control groups in mice.
人原发性肝癌的肿瘤异种移植瘤在裸鼠皮下生长。研究在肿瘤基底面积为0.8cm - 1.0cm的裸鼠中进行。对于放射免疫显像（RII）研究，给小鼠静脉注射1.11×10⁷Bq/只的¹³¹I - hepama - 1。注射后第4天所有肿瘤均清晰可见，直至第7天保持不变。¹³¹I - mIgG组未发现肿瘤图像。¹³¹I - Hepama - 1组放射性的肿瘤与肝脏比值从1.3增加到3.03，而¹³¹I - mIgG组从13.6%降至6.88%。对于放射免疫治疗（RIT）研究，腹腔注射¹³¹I - hepama - 1（1.85×10¹⁰Bq）。输注后第4周获得的肿瘤生长抑制率为70.5%。¹³¹I - hepama - 1组裸鼠的中位生存时间比对照组小鼠长得多。
